I like how drug corporations report mostly nothing but good news or just slightly negative to pump up their stock and their hopes, but then hide problems like actual negative effects just like the possibility of cancer. I can only stress that boosting your serotonin production by eating your favorite starchy and sweet munchies in calculated amounts at specific times can help turn off your desire for food.
A couple of weeks ago, an advisory panel to the FDA rejected endorsement of a new weight-loss medicine, Lorcaseri. The primary reason for rejection was concern that it may cause cancer. Rat research in which relatively high doses of the drug were tested had produced tumors. But it appears that the next reason for rejecting the medicine is that it just didn’t work very well.
Weight-loss drugs should cause weight loss. And Lorcaserin did, but in such small amounts that the drug’ s effectiveness barely met FDA standards. After a year, volunteers taking the drug lost only about 5.8% of their original body weight. As comparison, the people on placebo did even less well. They lost about 2.5% of their body weight.
If you only had 20 pounds to lose, 5.8 % of your starting weight might be acceptable. For example, if you were a woman weighing 140 pounds whose goal weight was 125 pounds, taking the drug for a year would allow you to lose about 8 pounds. And if those 8 pounds motivated you to continue losing weight after you no longer were on the drug, then taking it would have been very helpful. However, 8 pounds over 12 months is a very small amount of weight to lose, especially since the volunteers were all put on a diet and exercise program. If you had considerably more weight to lose, then you might get frustrated at how slowly you were losing it and stop the drug or the diet. So it is understandable that the weight-loss results were not substantial enough to win approval.
Meridia, a diet drug that has been sold for several years, has also been scrutinized recently because of concern over its side effects and weight-loss effectiveness. Then, for the next 3 plus years, the volunteers either continued to receive the drug or a placebo. The drug group lost about 4 more pounds over 3 years. This means that their total weight loss for about 3 and half years was the grand total of about 10 pounds.
People in the study were chosen because their health would have benefited from weight loss, i.e. they all suffered from cardiovascular disease, type-2 diabetes, or both. Unfortunately, neither their weight nor their health benefited from treatment with Meridia as the incidence of stroke, heart attacks and death were higher among those getting the drug.
So here are two weight-loss drugs producing micro amounts of weight loss with the potential to produce major side effects. Of course people get sick and may die from the effects of obesity itself. In all fairness one could say that any weight loss may be beneficial. But the slow rate of weight loss among people on both of these drugs indicates that not only were people not eating substantially less (otherwise they would have lost more weight), they must not have accepted the other lifestyle changes that promote and maintain weight loss.
No drug, by itself, can bring about the changes supporting permanent weight loss such as increasing physical activity, removing triggers to emotional overeating and reducing eating to a way of getting nourished rather than as a substitute for recreation and loneliness.
Weight-loss drugs should be considered “first responders” that come to the aid of the dieter when the diet program begins. By immediately decreasing food intake, the drug gives the dieter the sense that she is finally in control of her eating. Because she is no longer struggling every minute with whether or not she should be eating some forbidden food, she has the breathing room to develop a healthier eating style, to begin an exercise program and to identify triggers to emotional overeating and find activities that will replace chronic snacking.
The dieter has to understand that there is no “magic pill” that can bring about all these changes. A weight-loss drug is like a fireman who responds to a fire. The drug may dampen the flames of overeating but only the dieter can rebuild a healthy weight lifestyle.
What so many dieters don’t know is that their brains may help them do this, not including medicines. Their brains contain a neurotransmitter, which, while correctly activated, stops emotional overeating, adds energy so that exercise becomes probable and makes the people feel full after only moderate large amounts of food.
I’d like to take the chance to reiterate that carbohydrates can truly help people by increasing levels of serotonin, that ‘feel good’ substance, in the brain. A rise in serotnin production has been shown to cut aspirations and help weight loss. Nature has offered us with what we need to help ourselves.
A couple of weeks ago, an advisory panel to the FDA rejected endorsement of a new weight-loss medicine, Lorcaseri. The primary reason for rejection was concern that it may cause cancer. Rat research in which relatively high doses of the drug were tested had produced tumors. But it appears that the next reason for rejecting the medicine is that it just didn’t work very well.
Weight-loss drugs should cause weight loss. And Lorcaserin did, but in such small amounts that the drug’ s effectiveness barely met FDA standards. After a year, volunteers taking the drug lost only about 5.8% of their original body weight. As comparison, the people on placebo did even less well. They lost about 2.5% of their body weight.
If you only had 20 pounds to lose, 5.8 % of your starting weight might be acceptable. For example, if you were a woman weighing 140 pounds whose goal weight was 125 pounds, taking the drug for a year would allow you to lose about 8 pounds. And if those 8 pounds motivated you to continue losing weight after you no longer were on the drug, then taking it would have been very helpful. However, 8 pounds over 12 months is a very small amount of weight to lose, especially since the volunteers were all put on a diet and exercise program. If you had considerably more weight to lose, then you might get frustrated at how slowly you were losing it and stop the drug or the diet. So it is understandable that the weight-loss results were not substantial enough to win approval.
Meridia, a diet drug that has been sold for several years, has also been scrutinized recently because of concern over its side effects and weight-loss effectiveness. Then, for the next 3 plus years, the volunteers either continued to receive the drug or a placebo. The drug group lost about 4 more pounds over 3 years. This means that their total weight loss for about 3 and half years was the grand total of about 10 pounds.
People in the study were chosen because their health would have benefited from weight loss, i.e. they all suffered from cardiovascular disease, type-2 diabetes, or both. Unfortunately, neither their weight nor their health benefited from treatment with Meridia as the incidence of stroke, heart attacks and death were higher among those getting the drug.
So here are two weight-loss drugs producing micro amounts of weight loss with the potential to produce major side effects. Of course people get sick and may die from the effects of obesity itself. In all fairness one could say that any weight loss may be beneficial. But the slow rate of weight loss among people on both of these drugs indicates that not only were people not eating substantially less (otherwise they would have lost more weight), they must not have accepted the other lifestyle changes that promote and maintain weight loss.
No drug, by itself, can bring about the changes supporting permanent weight loss such as increasing physical activity, removing triggers to emotional overeating and reducing eating to a way of getting nourished rather than as a substitute for recreation and loneliness.
Weight-loss drugs should be considered “first responders” that come to the aid of the dieter when the diet program begins. By immediately decreasing food intake, the drug gives the dieter the sense that she is finally in control of her eating. Because she is no longer struggling every minute with whether or not she should be eating some forbidden food, she has the breathing room to develop a healthier eating style, to begin an exercise program and to identify triggers to emotional overeating and find activities that will replace chronic snacking.
The dieter has to understand that there is no “magic pill” that can bring about all these changes. A weight-loss drug is like a fireman who responds to a fire. The drug may dampen the flames of overeating but only the dieter can rebuild a healthy weight lifestyle.
What so many dieters don’t know is that their brains may help them do this, not including medicines. Their brains contain a neurotransmitter, which, while correctly activated, stops emotional overeating, adds energy so that exercise becomes probable and makes the people feel full after only moderate large amounts of food.
I’d like to take the chance to reiterate that carbohydrates can truly help people by increasing levels of serotonin, that ‘feel good’ substance, in the brain. A rise in serotnin production has been shown to cut aspirations and help weight loss. Nature has offered us with what we need to help ourselves.
没有评论:
发表评论